August 28, 2020 – A recent clinical trial conducted by KGK Science has found evidence to support a natural health product, Relieve-R (formerly Pain Bloc-R), having the ability to provide occasional pain relief and reduce inflammation in healthy adults. The 7-day, randomized, double-blind, placebo-controlled, crossover study, sponsored by LifeSeasons Inc., demonstrated statistical significance to reduce occasional aches and discomfort in twenty-seven healthy adults, ages 22-63, resulting in significant reductions in pain severity and musculoskeletal discomfort.
“The ability for a natural product, Relieve-R, to deliver pain relief and reduce inflammation with statistical significance is a milestone achievement,” says Najla Guthrie, President and CEO at KGK Science. “It provides consumers with a natural pain relief alternative for occasional aches and discomfort.”
Relieve-R is a natural health product developed by LifeSeasons, composed of vitamins B6, B12, D, white willow bark extract, Angelica root extract, acetyl L-carnitine HCl, caffeine, L-theanine, Benfotiamine, and L-tetrahydropalmatine, designed to ease discomfort by reducing inflammation, regulating hormones, and modulating neurotransmitters to promote muscle relaxation.
“Currently, there have been no studies investigating the pain-alleviating effects of a formula with a composition similar to Relieve-R,” says Dr. Mal Evans, Chief Scientific Officer at KGK Science. “However, the active dietary ingredients in Relieve-R seem to target multiple pain pathways and mechanisms. This is certainly an exciting finding as healthy participants reported clinically meaningful reductions in their average pain and pain severity over placebo.”
The study consisted of three, 7-day supplementation periods with Relieve-R, a positive control comparator, and placebo respectively, each separated by a 7-day washout period. Participants on Relieve-R experienced 16% greater relief of their average pain than those on placebo. Overall, participants reported significant reductions of 21.8% in pain severity and 34.1% in musculoskeletal discomfort, suggesting the potential role of Relieve-R as a safe and effective natural alternative to managing occasional aches and discomfort.
“Clinical studies give us a strong foundation for product development,” says Darrin Peterson, CEO at LifeSeasons. “Inspired by consumer experience, we support research in the dietary supplement field to provide confidence to individuals and their healthcare partners and to substantiate one of the core beliefs of our company: nature works.”
Read the full research paper for more details on this new research from KGK Science.
Pain Bloc-R Alleviates Unresolved, Non-Pathological Aches and Discomfort in Healthy Adults—A Randomized, Double-Blind, Placebo-Controlled, Crossover Study
Malkanthi Evans, Abdul M. Sulley, David C. Crowley, Jamie Langston, and Najla Guthrie
Nutrients 2020, 12(6), 1831
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