Do you have abdominal pain or discomfort? It could be more than you think.
Posted on Tue, 23 May 2017
Have you been experiencing frequent abdominal pain or discomfort that is out of the norm? Is this pain relieved by bowel movements or associated with a change in the frequency or form of your stool? If so, then you may be experiencing irritable bowel syndrome (IBS).
IBS is a gastrointestinal disorder that affects the large intestine and may cause: recurring abdominal pain or discomfort, abnormal stool frequency or form, diarrhea or constipation, bloating, and flatulence. Commonly, symptoms are experienced after ingestion of a meal, but may also occur spontaneously. These symptoms, as well as the anxiety that comes along with their anticipation, can drastically impact the quality of life for individuals suffering from this syndrome.
IBS is the most common functional bowel disorder, with studies estimating its prevalence in Europe and North America to be between 10 – 15 per cent, with an annual incidence rate of 1 – 2 per cent. However, these numbers may be under reported due to the non-specific nature of IBS symptoms that may be mistaken for other ailments. Those at highest risk of developing IBS include females, young people and individuals with a history of gastrointestinal infections. Furthermore, psychological symptoms such as depression and anxiety have been associated with the development of this syndrome, but it is unclear if these symptoms represent a cause or effect of IBS.
Due to the nature of IBS as a disorder of the gastrointestinal tract, it may also have impacts on health by influencing digestion. Once food is consumed it passes from the stomach to the small and large intestine where nutrients are absorbed. Because IBS can cause diarrhea or constipation, this will change the transit time of foods in the gastrointestinal tract and may lead to impairments in the absorption of many nutrients, in severe cases leading to nutritional anemia. Thus, while the common symptoms of IBS seem mild and do not lead towards a disease state, it is important to receive treatment to help in their management before more serious health complications arise.
Researchers across the globe including the Rome Foundation Working Team, a non-profit scientific organization examining functional gastrointestinal disorders, have recently recognized altered gut bacteria as a potential cause of IBS. Accordingly, probiotics have been investigated for the management of IBS symptoms as they can influence gut bacteria to create a more favourable profile. Emerging evidence in this area has revealed that these bacteria may play a beneficial role in reducing symptom generation, and as such may represent a novel avenue for the management of IBS symptoms.
KGK Science in London, offering expert assistance through human clinical trials since 1997, is currently conducting a clinical study to evaluate whether an investigational supplement containing two probiotic strains: Bifidobacterium longum and Lactobacillus paracasei can improve IBS symptoms. KGK’s clinical trials are conducted under the direction of a Medical Director and Principal Investigator. All studies are reviewed by an independent ethics review board, Health Canada and follow Good Clinical Practice. We are currently looking for participants who would be interested in being a part of this exciting new research.
All records relating to your identity and study participation are confidential as required by the Personal Information Protection and Electronic Documents Act. Each study has its own guidelines – eligibility criteria. To ensure the strongest results, researchers want study participants to be alike in key ways. Examples of eligibility criteria for a treatment trial might be age, gender, and/or your previous medical history.
To participate in KGK Science’s clinical research on probiotics and IBS, you must be male or female over the age of 18, experience recurrent abdominal pain or discomfort at least 2 days/month in the last 3 months which is relieved by defecation and/or pain onset is associated with a change in stool frequency or form. Additional information will be determined upon telephone screening. There are no out-of-pocket expenses for you to join this clinical trial, other than your travel expenses to and from the clinic site. Parking at One London Place will be validated, or TLC fare provided and participants will be compensated up to $500 for their time.