Evolution Forged an Alliance Between Plants, Microbes, and Us

Posted on Fri, 08 Feb 2019  Comments: 1

By the Science Editorial Staff at Amazentis


Plants occasionally have an interest in our health, sometimes with the help of bacteria.

Around 5000 years ago, in the middle eastern region known as the Fertile Crescent, Sumerians were already cultivating dozens of plants, including the ancestors of our modern wheat, lentils, peas, and barley. The resulting diet was surprisingly balanced in carbohydrates and proteins. Dating from the same period, a cuneiform tablet describes the medicinal properties of thyme, willow, pear or dates (1).

Of course, nutritional value is the main reason why we added plants to our table. Just think of the potato and how fast it propagated from its Peruvian origin. A couple centuries only after European discovered this exceptionally nutrient-rich tuber, it was providing commoners of the Old World with most of their daily calories.

We also pick plants for their flavor. Most spices and many vegetables own their distinctive taste from compounds which help them fight pests. As much as they are attractive to us, the scents of mint, basil or rosemary are toxic or repulsive to foraging insects. The slight bitterness of cabbage is a warning sign: I am toxic. Yet, the bitter compound is not only harmless to us (unless eaten in huge quantities), but also delicious.

Nutriment and flavors are important, but what about health? It is generally thought that our ancestors gradually discovered medicinal properties of plants. Modern science sometimes confirms these century-old assumptions.

Research Program - Energy, Endurance & Stamina

Fruits, nuts, and berries want to be eaten

When it comes to many fruits, nuts, and berries, the plants chose us.

Bright colors, sought-after sweetness, and fatty content attract birds, rodents, bears, humans, and many other animals. Well-protected seeds often pass through digestive tracts and end up disseminated and ready to hatch – coated with a free layer of fertilizer! Nuts are typically stored in the ground by small mammals for the colder months or accidentally dropped by birds. As a result, countless trees owe their existence to a forgetful squirrel or an awkward raven.

Berries have interests in our health… and so do bacteria

Many fruit-bearing plants go one step further in their strategy. They don’t just attract seed disseminators: they keep them healthy. Certain fruits, nuts, and berries are known to provide fairly large quantities of antioxidants and vitamins. Amongst these, the pomegranate is perhaps one of the first cultivated fruits in human history known to have many health promoting and anti-aging benefits.

These fruits also contain other molecules which did not catch our attention until recently. Called ellagitannins, these compounds remained unnoticed for a good reason: they have no obvious health benefit.

When we absorb ellagitannins from pomegranates, walnuts, and blackberries, bacteria in our digestive tract break down these big molecules into smaller ones, which we can assimilate and send into our bloodstream. Among these byproduct metabolites, we find Urolithin A.

Most gut bacteria have a selfish interest in helping us. First, a healthy host is nothing less than a safe home. Second, vigorous individuals have greater chances of reproducing and transmitting their bacteria to their offspring (2). By making us healthier, gut bacteria give themselves an evolutionary edge. This is why science discovers more and more of their positive effects (3), from fine-tuning our immune system to providing several beneficial molecules – including Urolithin A. However, not everyone has the right gut bacteria to transform ellagitannins and generate Urolithin A (4).

It matters, because Urolithin A has been proven to enhance the cellular and mitochondrial health in pre-clinical studies. Did you know that mitochondria started off as independent bacteria, too? During evolution, these bacteria developed a symbiotic relationship with host cells leading to their becoming integrated with the host cells’ machinery –the so-called “microbiome-mitochondrial” axis of health.

As a result of Urolithin A’s role, nematode worms live longer, and rodents show an increased endurance (5). Human trials are on their way, but we already know that Urolithin A triggers our cellular activity in a comparable manner (6).

The beauty of it is that none of it would work without a million years of co-evolution between plants, animals, and bacteria. It is now up to us to take this process, fine-tuned by evolution, and use it to keep our cells, and muscles, healthy.



  1. Alamgir, A. N. M. Therapeutic Use of Medicinal Plants and Their Extracts: Volume 1: Pharmacognosy. (2017)
  2. Pannaraj, P. S. et al. Association Between Breast Milk Bacterial Communities and Establishment and Development of the Infant Gut Microbiome. JAMA Pediatr., 171, 647–654 (2017).
  3. Nicholson, J. K. et al. Host-gut microbiota metabolic interactions. Science, 336, 1262–1267 (2012).
  4. Gonza╠ülez-Barrio, et al. Bioavailability of Anthocyanins and Ellagitannins Following Consumption of Raspberries by Healthy Humans and Subjects with an Ileostomy. J. of Ag. and Food Chem., 58(7), 3933–3939 (2010).
  5. Ryu, D. et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat. Med., 22, 879–888 (2016).
  6. Singh, A. et al. Orally administered Urolithin A is safe and modulates muscle and mitochondrial biomarkers in elderly. Innovation in Aging, 1, 1223–1224 (2017).

Published with permission from Amazentis SA

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  • Mary Lewis

    By Mary Lewis Tue, 26 Feb 2019

    I would be interested in finding out more about this and if there will be a study on it, as well if i might qualify for the study
    once you do start the study
    Thank you, looking forward to hearing back from you
    Mary Lewis